Alias (NCBI), SCFR (Stem Cell Factor Receptor). CD117. HGNC (Hugo), KIT. HGNC Alias symb, CD117. SCFR. C-Kit. HGNC Alias name, mast/stem cell growth
Download scientific diagram | c-Kit signal transduction and its function [80]. from publication: Hematopoietic Stem Cell Molecular Targets and Factors Essential
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The Omni-C™ Kit EpiTect Hi-C Kit for high resolution mapping of chromatin folding, high quality assembly of genome sequences, and haplotype phasing. Apr 30, 2013 PE anti-human CD117 (c-kit) Antibody - CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. Human c-kit oncogene on human chromosome 4. (Abstract) Am. J. Hum. Genet. 37: A143, 1985. Mattei, M. G., d'Auriol, L., Andre, C., Passage, E., Mattei, J. F., The Chlorine Institute Tank Car/Truck Emergency Kit "C" includes devices and tools to contain leaks in and around the pressure relief device and angle valves of FPP C-41 Home Development Kit - 1 LiterDevelop Color Negatives (C-41) at home! What will I need?
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B-ALL. ☐ c-KIT mutationsanalys –. Mastocytos, AML (kodon 816). ☐ Övrigt: EGFR-mutationsanalys. ☐ cfDNA/plasma. ☐ FFPE (Analys av TKI-.
Detection of c-Kit mutations in exon 11 predicts a high rate of metastasis and mortality in canine MCTs, but both MCTs and GISTs with such mutations have been shown to respond well to tyrosine kinase-inhibiting (TKI) therapies, e.g. toceranib phosphate (Palladia) and masitinib mesylate (Kinavet-CA). 2021-04-06 · The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor.
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NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. KIT (c-KIT) Mutation Analysis As of November 1, 2020, we will discontinue future development for Internet Explorer To have a better experience, please upgrade to Microsoft Edge , Google Chrome , or Firefox . c-kit-targeted imaging of gastrointestinal stromal tumor using radiolabeled anti-c-kit monoclonal antibody in a mouse tumor model.
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Some examples of normal tissue stained with c-Kit pharmDx and recommended reagents are summarized in the table below. Detection of c-Kit mutations in exon 11 predicts a high rate of metastasis and mortality in canine MCTs, but both MCTs and GISTs with such mutations have been shown to respond well to tyrosine kinase-inhibiting (TKI) therapies, e.g. toceranib phosphate (Palladia) and masitinib mesylate (Kinavet-CA). 2021-04-06 · The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor.
It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Bi-directional sequencing of KIT exons 8, 9, 11, 13 and 17 for detection of activating mutations including the common mutation D816V. For solid tumors, tumor enrichment is performed before extraction. CD117, also known as c-kit and SCF R, is the cellular receptor for Stem Cell Factor (SCF), also named c-kit ligand, mast cell growth factor, and steel factor.
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The targeted therapeutics nilotinib and sunitinib have shown efficacy in treating KIT overactive patients, and are in late-stage trials in melanoma and GIST. c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors (1,2). It plays a critical role in activation and growth in a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells (3).
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